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    Multidrug-resistant Organisms (MDROs) are germs, typically bacteria or fungi, that are resistant to one or more antimicrobial drugs. This means that MDROs may be more difficult to treat than other infections, and this can cause prolonged health care stays and increased costs. Many MDROs spread in health care settings and the Pennsylvania Department of Health, Division of Healthcare Associated Infection Prevention, conducts public health response and prevention activities for MDROs including carbapenemase-producing organisms (CPOs) and Candida auris. We developed the following resources, training, and tools to help health care facilities prevent transmission of MDROs and respond when they are detected. You can also learn more about MDROs from CDC webpage Management of Multidrug-Resistant Organisms in Healthcare Settings.